The first person to be diagnosed with Ebola within the US has died, Texas hospital officials have said.
Thomas Eric Duncan, 42, who caught the virus in his native Liberia, was being kept in isolation in a Dallas hospital and receiving experimental drugs.
The news came shortly after US Secretary of State John Kerry urged all nations to boost their response to combat the virus.
Duncan, who worked as a driver for a courier company, tested positive in Dallas, Texas, on 30 September, 10 days after arriving on a flight from Monrovia via Brussels. He become ill a few days after arriving in the US but after going to hospital and telling them he had been to Liberia he was sent home with antibiotics.
Four days later, he was placed in isolation but his condition continued to worsen and this week he was given an experimental drug.
Ten people he came into contact with are being monitored for symptoms.
Meanwhile, the first infection in Europe was confirmed in Spain, where a nurse who treated an Ebola victim in Madrid contracted the virus herself.
Teresa Romero, is the first person known to have contracted the deadly virus outside West Africa.
She had treated two Spanish missionaries who later died from Ebola.